Z-ASPARTIC ACID-OME
Z-L-aspartic acid 1-methyl ester
CAS: 4668-42-2
Molecular Formula: C13H15NO6
Z-ASPARTIC ACID-OME - Names and Identifiers
| Name | Z-L-aspartic acid 1-methyl ester |
| Synonyms | Z-ASP-OME Z-Asp-OMe Z-L-ASP-OME Z-ASPARTIC ACID-OME Z-L-Aspartic acid Methylester Z-L-aspartic acid 1-methyl ester Z-L-ASPARTIC ACID 1-METHYL ESTER Z-L-ASPARTIC ACID ALPHA-METHYL ESTER Cbz-L-Aspartic Acid alpha-Methyl Ester N-CBZ-L-ASPARTIC ACID ALPHA-METHYL ESTER N-BENZYLOXYCARBONYL-L-ASPARTIC ACID 1-METHYL ESTER N-ALPHA-BENZYLOXYCARBONYL-L-ASPARTIC ACID ALPHA-METHYL ESTER (3S)-3-{[(benzyloxy)carbonyl]amino}-4-methoxy-4-oxobutanoic acid (non-preferred name) |
| CAS | 4668-42-2 |
| InChI | InChI=1/C13H15NO6/c1-19-12(17)10(7-11(15)16)14-13(18)20-8-9-5-3-2-4-6-9/h2-6,10H,7-8H2,1H3,(H,14,18)(H,15,16)/t10-/m0/s1 |
Z-ASPARTIC ACID-OME - Physico-chemical Properties
| Molecular Formula | C13H15NO6 |
| Molar Mass | 281.26 |
| Density | 1.304±0.06 g/cm3(Predicted) |
| Melting Point | 89.0 to 93.0 °C |
| Boling Point | 498.9±45.0 °C(Predicted) |
| Flash Point | 255.6°C |
| Solubility | soluble in Methanol |
| Vapor Presure | 8.95E-11mmHg at 25°C |
| Appearance | Crystallization |
| Color | White to Almost white |
| BRN | 4813538 |
| pKa | 4.09±0.19(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 1.539 |
| MDL | MFCD00083277 |
Z-ASPARTIC ACID-OME - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R20/22 - Harmful by inhalation and if swallowed. R37 - Irritating to the respiratory system R41 - Risk of serious damage to eyes |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| HS Code | 29224999 |
Z-ASPARTIC ACID-OME - Introduction
Z-L-aspartic acid 1-methyl ester(Z-L-aspartic acid 1-methyl ester) is a chemical compound, its properties, uses, preparation methods and safety information are as follows:
1. nature:
Z-L-aspartic acid 1-methyl ester is a colorless solid, stable at room temperature. It is readily soluble in common organic solvents such as dichloromethane, methanol and dimethylformamide.
2. use:
Z-L-aspartic acid 1-methyl ester is often used in organic synthesis, especially as a temporary protective group when synthesizing polypeptides and proteins. It can achieve control of specific reactions by selectively protecting the amino group on the carboxyl group of aspartic acid (Z protection).
3. Preparation method:
Z-L-aspartic acid 1-methyl ester can be obtained by protecting the carboxyl group of L-aspartic acid and then reacting with a methylating reagent in methanol. The specific method includes first reacting L-aspartic acid with N-hydroxybenzyl carbamate (Cbz-Cl) to generate N-Cbz-L-aspartic acid, and then reacting the product of the previous step with methyl iodide to obtain Z-L-aspartic acid 1-methyl ester using methanol as solvent.
4. Safety Information:
In the use and handling of Z-L-aspartic acid 1-methyl ester, should follow the laboratory safety procedures. It is an organic compound that may pose a health risk to humans when exposed, inhaled or ingested in excess. Therefore, it is necessary to take appropriate protective measures during use and storage, such as wearing protective gloves, glasses and providing adequate ventilation outside the laboratory. In the event of accidental exposure or ingestion, seek medical assistance immediately and provide relevant safety data.
1. nature:
Z-L-aspartic acid 1-methyl ester is a colorless solid, stable at room temperature. It is readily soluble in common organic solvents such as dichloromethane, methanol and dimethylformamide.
2. use:
Z-L-aspartic acid 1-methyl ester is often used in organic synthesis, especially as a temporary protective group when synthesizing polypeptides and proteins. It can achieve control of specific reactions by selectively protecting the amino group on the carboxyl group of aspartic acid (Z protection).
3. Preparation method:
Z-L-aspartic acid 1-methyl ester can be obtained by protecting the carboxyl group of L-aspartic acid and then reacting with a methylating reagent in methanol. The specific method includes first reacting L-aspartic acid with N-hydroxybenzyl carbamate (Cbz-Cl) to generate N-Cbz-L-aspartic acid, and then reacting the product of the previous step with methyl iodide to obtain Z-L-aspartic acid 1-methyl ester using methanol as solvent.
4. Safety Information:
In the use and handling of Z-L-aspartic acid 1-methyl ester, should follow the laboratory safety procedures. It is an organic compound that may pose a health risk to humans when exposed, inhaled or ingested in excess. Therefore, it is necessary to take appropriate protective measures during use and storage, such as wearing protective gloves, glasses and providing adequate ventilation outside the laboratory. In the event of accidental exposure or ingestion, seek medical assistance immediately and provide relevant safety data.
Last Update：2024-04-09 20:48:19
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View History
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